Our Research
Our research focuses on three areas:
(i) vertebrate embryogenesis- how do signals, non-coding RNAs, and chromatin influence the fate and movement of cells?(ii) sensory neuron development and function - how does an organism sense potentially harmful stimuli?
(iii) sleep and wakefulness - what are the genes and circuits that regulate sleep?
New Publications NEWS
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Genomics:
Zebrafish earns its
stripes. Morphogen
transport. Optical
control of metabotropic glutamate
receptors. A
large-scale
zebrafish gene knockout resource
for the genome-wide study of gene function. The
Tangential Nucleus Controls a
Gravito-inertial Vestibulo-ocular Reflex. Attenuation
of Notch and Hedgehog signaling is
required for fate specification in the spinal cord. The
Tangential Nucleus Controls a
Gravito-inertial Vestibulo-ocular Reflex.
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April
2013 Second year graduate student from our lab, Tessa Montague has received The National Defense Science and Engineering Graduate (NDSEG) Fellowship 
Congratulations,
Tessa!
You can read the story on the MCB News Webpage Jeff Farrell has joined our lab as a postdoc. He completed his PhD in Patrick O'Farrell's lab at UCSF. Jeff has received a fellowship from The Jane Coffin Childs Memorial Fund for Medical Research.  -------------------------------------------------------------------------------------------------------------------------- March 2013 Steve Zimmerman has received the 2013 Dean's Distinction Award. 
Congratulations,
Steve!
Pictured: Steve with Harvard Faculty of Arts and Sciences Dean Mike Smith -------------------------------------------------------------------------------------------------------------------------- January 2013 Summer Thyme has been named a Damon Runyon Fellow by The Damon Runyon Cancer Research Foundation, a nonprofit organization focused on supporting innovative early career researchers. 
Congratulations,
Summer!
You can read the story in the Harvard Gazette -------------------------------------------------------------------------------------------------------------------------- December 2012 Jennifer Li and Drew Robson have successfully defended their PhD theses this month. Jen's dissertation title is 'Identification of an Operant Learning Circuit by Whole Brain Functional Imaging in Larval Zebrafish', Drew's dissertation title is 'Thermal navigation in larval zebrafish'. 
Congratulations,
Dr Li and Dr
Robson!
Our postdoc Farhad Imam has started his new job as an Assistant Professor at UC San Diego. 
Congratulations,
Farhad! We'll miss you in the lab! -------------------------------------------------------------------------------------------------------------------------- September 2012 Summer Thyme has joined our lab as a postdoc. She finished her PhD in Dr David Baker's lab at the University of Washington. In our lab Summer will work on developing tools for genome and chromatin manipulation in zebrafish.
--------------------------------------------------------------------------------------------------------------------------- August 2012 Third year graduate student from our lab, Guo-Liang “Chewie” Chew has received the prestigious HHMI International Fellowship from the Howard Hughes Medical Institute. 
Congratulations,
Chewie!
You can read the story on the MCB News Webpage -------------------------------------------------------------------------------------------------------------------------- June 2012 Recent Papers: Attenuation of Notch and Hedgehog Signaling Is Required for Fate Specification in the Spinal Cord [PLoS Genetics] P Huang, F Xiong, SG Megason, AF Schier Bivalent histone modifications in early embryogenesis [review in Current Opinion in Cell Biology] NL Vastenhouw and AF Schier Information for Zebrabow transgenic lines made by Y.A. Pan is available for download [download here] -------------------------------------------------------------------------------------------------------------------------- May 2012 Read the latest Science issue for an exciting story from our lab about reaction-diffusion patterning in development!  Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system. Müller P, Rogers KW, Jordan BM, Lee JS, Robson D, Ramanathan S, Schier AF. Science. 2012 May You can read a summary of the story on the MCB News Webpage -------------------------------------------------------------------------------------------------------------------------- April 2012 Z-Seq Website is up and running!
We employ high-throughput sequencing technologies to identify and study chromatin- and RNA-based gene regulatory mechanisms that control embryogenesis. Our Z-Seq website facilitates easy access to our published data sets. Data can be directly downloaded or conveniently viewed in the Integrative Genomics Viewer (IGV) or in the UCSC genome browser. Our Z-Seq website will be updated as more data becomes published. |
