Stowe, S.D., Olson, A.L., Losick, R., Cavanagh, J., Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis. Biomol NMR Assign. (2013). (PDF)
Bottcher, T. Kolodkin-Gal, I., Kolter, R., Losick, R., and Clardy, J., Synthesis and Activity of Biomimetic Biofilm Disruptors. Journal of the American Chemical Society. 135: 2927−2930 (2013). (PDF)
Vlamakis, H. Chai, Y., Beauregard, P., Losick, R. Kolter, R. Sticking together: building a biofilm the Bacillus subtilis way. Nature Reviews Microbiology. (3):157-68 (2013). (PDF)
Wilking, J.N., Zaburdaev, V., De Volder, M., Losick, R., Brenner MP, Weitz DA. Liquid transport facilitated by channels in Bacillus subtilis biofilms. Proc. Natl. Acad. Sci USA (2012). (PDF)
Traag, B.A, Pugliese, A., Eisen, J.A, Losick, R. Gene Conservation among Endospore-Forming Bacteria Reveals Additional Sportulation Genes in Bacillus subtilis. J. Bacteriol (2012). (PDF)
Chen, Y., Chai, Y., Guo, J.H., Losick, R. Evidence for cyclic di-GMP-mediated signaling in Bacillus subtilis. J. Bacteriol 194:5080-5090 (2012). (PDF)
Chen, Y., Yan, F., Chai, Y., Liu, H., Kolter, R., Losick, R., and Guo, J. Biocontrol of tomato wilt disease by Bacillus subtilis isolates from natural environments depends on conserved genes mediating biofilm formation. Environmental Microbiology (2012). (PDF)
Rubinstein, S.M., Kolodkin-Gal, McLoon, A., Chai, L., Kolter, R., Losick, R., Weitz, D.A Osmotic Pressure Can Regulate Martrix Gene Expression in Bacillus subtilis. Molecular Microbiol.1365-2958 (2012). (PDF)
Chai, Y., Beauregard PB, Vlamakis, H., Losick, R., Kolter, R. Galactose Metabolism Plays a Crucial Role in Biofilm Formation by Bacillus subtilis. Mbio pii: e00184-12 (2012). (PDF)
Chen, Y., Cao, S., Chai, W., Clardy, J., Kolter, R., Guo, J., and Losick, R. A Bacillus subtilis Sensor Kinase Involved in Triggering Biofilm Formation on the Roots of Tomato Plants. Molecular Micro. 85:418-430 (2012). (PDF)
Kolodkin-Gal, I., Cao, S. Chai, L., Böttcher, T. Kolter, R., Clardy, J., Losick, R. A Self-produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide. Cell 149:684-692 (2012). (PDF)
Shank, E. A., Klepac-Ceraj, V.,Collado-Torres, L., Powers, G.E., Losick, R. and Kolter, R. Interspecies interactions that result in Bacillus subtilis forming biofilms are mediated mainly by members of its own genus. Proc. Natl. Acad. Sci USA
108:1236-42 (2011). (PDF)
Chastanet, A. and Losick, R. Just-In-Time control of Spo0A Synthesis in Bacillus subtilis by Multiple Regulatory Mechanisms. J. Bacteriol 193:(2011). (PDF)
Hochbaum, Al, Kolodkin-Gal, I., Foulston, L., Kolter, R., Aizenberg, J., Losick R. Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. J. Bacteriol 20:5616-22 (2011). (PDF)
Anderson, WA, Banerjee, U., Drennan, C.L, Elgin, S.C.R, Epstein, I.R., Handelsman, J. Hatfull, G.F., Losick, R., O'Dowd, D. K, Olivera, B.M. Strobel, S.A., Walker, G.C., Warner I.M. Changing the Culture of Science Education at Research Universities. Science 331 (6014): 152-153 (2011). (PDF)
Banse, A.V., Hobbs, E.C., Losick, R. Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein Med in Bacillus subtilis. J. Bacteriol (2011). (PDF)
Romero. D, Vlamakis, H., Losick, R., Kolter, R. An Accessory Protein Required for Anchoring and Assembly of Amyloid Fibers in B. subtilis Biofilms. Molecular Microbiol. 80:1155-11168. (2011).(PDF)
Chai, Y., Norman, T., Kolter, R., Losick, R. Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis. EMBO J. 30:1402-1413. (2011). (PDF)
McLoon, A.L., Guttenplan, S.B., Kearns, D.B., Kolter, R., Losick R. Tracing the domestication of a biofilm-forming bacterium. J. Bacteriol. 193:2027-2034 (2011). (PDF)
Rahn-Lee, L., Merrikh, H, Grossman, A.D., and Losick, R. The Sporulation Protein SirA Inhibits the Binding of DnaA to the Origin of Replication by Contacting a Patch of Clustered Amino Acids. J. Bacteriol. 193:1302-1307 (2011). (PDF)
McLoon, AL, Kolodkin-Gal, I., Rubinstein, SM, Kolter, R., and Losick, R. Spatial Regulation of Histidine Kinases Governing Biofilm Formation in Bacillus subtilis. J. Bacteriol.193:2027-2034 (2011). (PDF)
Camp, A.H., Wang, A.F., and Losick, R. A Small Protein Required for the Switch from F to G during Sporuation in Bacillus subtilis, in Bacillus subtilis, J. Bacteriology 193:116-124 (2011). (PDF)
Shemesh, M., Kolter, R., and Losick, R. The Biocide Chlorine Dioxide stimulates Biofilm Formation by Activation of the Histidine Kinase KinC. J. Bacteriol. 192:6352-56 (2010). (PDF)
Rudner, R. And Losick, R. Protein Subcellular Localization in Bacteria. p. 51-64 In Cell Biology of Bacteria Cold Spring Harbor Laboratory Press Ed. Lucy Shapiro and Richard Losick. (2010). (PDF)
Schmalish, M, Maiques, E., Nikolov, L, Camp, A.H, Chevreux, B., Muffler, A., Rodriguez, S. Perkins, J. and Losick, R. Small Genes under Sporulation Control in the Bacillus subtilis genome. J. Bacteriol. 192:6352-56 (2010). (PDF)
Chai, Y., Kolter, R., Losick, R. Reversal of an Epigenetic Switch Governing Cell Chaining in Bacillus subtilis by Protein Instability. Molecular Microbiol. 78:218-29 (2010). (PDF)
Aguilar, C.,Vlamakis, H., Guzman, A., Losick, R. and Kolter, R. KinD Is a Checkpoint Protein Linking Spore Formation to Extracellular-Matrix Production in Bacillus subtilis Biofilms mBio 1:e00035-10 (2010). (PDF)
Chastanet, A., Vitkup, D., Yuan, G, Norman, T., Liu, J., Losick, R. Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis protein Proc. Natl. Acad. Sci 107:8486-8491 (2010). (PDF)
Kolodkin-Gal, I., Romero, D., Cao, S., Clardy, J., Kolter, R., Losick, R. D-Amino Acids Trigger Biolfilm Disassembly Science 328:627-629 (2010). (PDF)
Subramaniam, A.B., Lecuyer, S., Ramamurthi, K.S., Losick, R., and Stone, H.A. Particle/Fluid Interface Replication as a Means of Producing Topographically Patterned Polydimethylsiloxane Surfaces for Deposition of Lipid Bilayers. Adv Mater. 22:1-6 (2010). (PDF)
Chai, Y., Norman, T., Kolter, R., Losick, R. An epigenetic switch governing daughter cell separation in Bacillus subtilis . Genes & Development 23:1631-1638 (2010). (PDF)
Romero, D, Aguilar C, Losick R,Kolter R., Amyloid Fibers Provide Structural Integrity to Bacillus subtilis Biofilms, Proc. Natl. Acad. Sci. 107:2230-2234 (2010). (PDF)
Traag, B., Driks, A., Stragier, P., Bitter, W., Broussarde,G., Hatfull, G., Chu, F., Adams, K., Ramakrishnan, L., and Losick, R. Do mycobacteria produce endospores? Proc. Natl. Acad. Sci. USA 107:878-881 (2010). (PDF)
Shapiro, L., McAdams, H., Losick, R. Why and How Bacteria Localize Proteins. Science 3261225-1228 (2009). (PDF)
Chai, W., Kolter, R. and Losick, R. A Widely Conserved Gene Cluster Required for Lactate Utilization in Bacillus subtilis and its involvement in biofilm formation. J. Bacteriol 191: 2423-2430 (2009). (PDF)
Lopez, D., Vlamakis, H., Losick, R., Kolter, R. Cannibalism enhances biofilm development in Bacillus subtilis Molecular Microbiol. 74:609-618 (2009). (PDF)
Chai, Y., Kolter, R., Losick R. Paralogous Antirepressors Acting on the Master Regulator for Biolfilm Formation in Bacillus subtilis. Molecular Microbiol 74:876-877 (2009). (PDF)
López, D., Vlamakis, H., Losick, R., Kolter, R. Paracrine signaling in a bacterium. Genes & Development 23:1631-1638 (2009). (PDF)
Lue, R., and Losick, R. A handbook for Hands-On Learning Science 323:40-42 (2009). (PDF)
Ramamurthi, K. and Losick, R. Ramamurthi, K. and Losick, R. Negative membrane curvature as a cue for subcellular localization of a bacterial protein Proc. Natl. Acad. Sci. USA 106:13541-13545 (2009). (PDF)
Camp., A.H. and Losick, R. A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis. Genes & Development 23:1014-1024 (2009). (PDF)
Rahn-Lee, L., Gorbatyuk, B.,Skovgaard, O., Losick, R. The Conserved Sporulation Protein YneE Inhibits DNA Replication in Bacillus subtilis. J Bacteriol., 191: 3736-3739 (2009). (PDF)
Ramamurthi, K. and Losick, R. Geometric Cue for Protein Localization in a Bacterium (2009) Science 323:1354-1357 (2009). (PDF)
Lopez, D., Fischbach, M.A., Chu, F., Losick, R., and Kolter, R. Structurally diverse natural products that cause Potassium Leakage Triggers Multiellularity in a Bacterium. Proc. Natl. Acad. Sci. USA 106:280–285 (2009). (PDF)
Banse A.V., Chastanet A., Rahn-Lee L., Hobbs E.C., Losick R. Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis. 105:15547-52 Proc. Nat. Acad. Sci. USA (2008). (PDF)
Kain J., He G.G., Losick R. Polar localization and compartmentalization of ClpP proteases during growth and sporulation in Bacillus subtilis. J Bacteriol. 190:6749-57 (2008). (PDF)
Ramamurthi, K.S., and Losick R. Grasping at Origins Cell 134:916-918 (2008). (PDF)
Kontnik R., Bosak T., Butcher R.A., Brocks J.J., Losick R., Clardy J., Pearson A. Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores. Org Lett. 10:3551-4 (2008). (PDF)
Ramamurthi KS, Losick R. ATP-driven self-assembly of a morphogenetic protein in Bacillus subtilis. Molec. Cell. 31:406-14 (2008). (PDF)
Camp, A.H., and Losick, R. A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels. Molecular Microbiol. 69:402-417 (2008). (PDF)
Chu, F., Kearns, D.B., McLoon, A., Chai, Y., Kolter, R., and Losick R. A novel regulatory protein governing biofilm formation in Bacillus subtilis. Molecular Microbiol. 68:1117-1127 (2008). (PDF)
Earl AM, Losick R, Kolter R. Ecology and genomics of Bacillus subtilis. Trends Microbiol. 16:269-75 (2008).(PDF)
Bosak, T. Losick, R., and Pearson, A. A polycyclic terpenoid that alleviates oxidative stress. PNAS 105:6725-6729 (2008). (PDF)
Handler, A.A., Lim, J.E., and Losick, R. Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis. Molecular Microbiol. 68:588-599 (2008). (PDF)
Losick, R. and Desplan, C. Stochasticity and Cell Fate. Science 320:65-68 (2008). (PDF)
Vlamakis, H., Aguilar, C., Losick, R., Kolter, R. Control of cell fate by the formation of an architecturally complex bacterial community. Genes and Development 22:945-953 (2008). (PDF)Chai Y, Chu F, Kolter R, Losick R. Bistability and biofilm formation in Bacillus subtilis. Molecular Microbiology (2008). (PDF)
Aguilar C, Vlamakis H, Losick R, Kolter R. Thinking about Bacillus subtilis as a multicellular organism. Current Opinion in Microbiology 10:638-643 (2007). (PDF)
Ferguson, C.C., Camp, A. H., Losick, R. gerT, a newly discovered germination gene under the control of the sporulation transcription factor sK in Bacillus subtilis. J Bacteriol 189:7681-7689. (2007) Aug 24. (PDF)
Chastanet A., Losick R. Engulfment during sporulation in Bacillus subtilis is governed by a multi-protein complex containing tandemly acting autolysins. Molecular Microbiology, 64:139-152 (2007). (PDF)
Earl, A. , Losick, R., and Kolter, R. Bacillus subtilis Genome Diversity
J. Bacteriol 189: 1163-1170 (2007). (PDF)
Ramamurthi, K.S., Clapham, K.R., Losick, R. Peptide anchoring spore coat assembly to the outer forespore membrane in Bacillus subtilis. Molecular Microbiology, 62:1547-1557 (2006). (PDF)
Bassler, B. and Losick, R. Bacterially speaking. Cell 125: 237-246 (2006). (PDF)
Dubnau, D. and Losick, R. Bistability in bacteria. Molecular Microbiology, 61:564-572 (2006). (PDF)
Ellermeier, C.D. and Losick, R. Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis. Genes & Development 20: (2006). (PDF)
Wang, S.T., Setlow, B., Conlon, E.M., Lyon, J.L., Imamura, D., Sato, T., Setlow, P. Losick, R., and Eichenberger, P. The forespore line of gene expression in Bacillus subtillis. J. Molec. Biol. 358:16-37 (2006). (PDF)
Ellermeier, C.D., Hobbs, Errett C., Gonzalez-Pastor, J.E., Losick R. A Three-Protein Signaling Pathway Governing Immunity to a Bacterial Cannibalism Toxin Cell 124:549-559 (2006). (PDF)
Branda, S., Chu, F., Kearns, D., Losick, R., and Kolter, R. A major protein component of the Bacilllus subtilis biofilm matrix. Molecular Microbiology 59:1229-1238 (2006) (PDF).
Silvaggi, J., Perkins, J. and Losick, R.Genes for Small, Noncoding RNAs under Sporulation Control in Bacillus subtilis. J. Bacteriol 188:532-541 (2006). (PDF)
Chu, F., Kearns, D., Branda, S, Kolter, R., and Losick, R. Targets of the master regulator of biofilm formation in Bacillus subtilis. Molecular Microbiology 59:1216-1228 (2006). (PDF)
Kearns, D.B. and Losick R. Cell populations heterogeneity during growth of Bacillus subtilis Genes & Development 19:3083-3094 (2005). (PDF)
Silvaggi, J, Perkins, John B., and Losick, R. Small untranslated RNA antitioxin in Bacillus subtilis J. Bacteriol 187:6641-6650 (2005). (PDF)
Fujita, M. and Losick, R. Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A. Genes & Development 19:2236-2244 (2005). (PDF)
Dworkin, J., and Losick, R. Developmental commitment in a Bacterium. Cell 121:401-409 (2005). (PDF)
Carniol, K., Ben-Yehuda, S., King, N., and Losick, R. Genetic Dissection of the sporulation Protein SpoIIE and its role in asymmetric division in Bacilllus subtilis. J. Bacteriol 187:3511-3520 (2005). (PDF)
Ramamurthi, K. S., and Losick, R.M. Protein Localization: Reach out and Touch the Forespore. Current Biology. 15:R165-R167. (2005) (PDF)
Ben-Yehuda, S., Fujita, M., Liu, X., Gorbatyuk, B., Skoko, D., Yan J., Marko, J.F., Liu, J.S., Eichenberger, P., Rudner, D. and Losick, R. Defining a centromere-like Element in Bacillus subtilis by identifying the binding sites for the chromosome-anchoring protein RacA. Molec. Cell, 17: 773-782 (2005). (PDF)
Fujita, M, Gonzalez-Pastor, E, and Losick, R. High- and Low-Threshold Genes in the Spo0A regulon of Bacillus subtilis. J. Bacteriol. 187:1357-1368 (2005). (PDF)
Kearns, D., Chu, Frances, Branda, S., Kolter, R., and Losick R. A Master regulator for biofilm formation by Bacillus subtilis. Molec Microbiol 55:739-749 (2005). (PDF)
Silvaggi, J., Popham, D., Driks, A., Eichenberger, P., Losick, R. Unmasking Novel Sporulation Genes in Bacillus subtilis. J. Bacteriol 186:8089-8095 (2004). (PDF)
Eichenberger, P., Fujita, M., Jensen, S.T., Conlon, E.M., Rudner, D.Z., Wang, S.T., Ferguson, C., Haga, K., Sato, T., Liu, J.S., Losick, R. The Program of Gene Transcription for a Single Differentiating Cell Type during Sporulation in Bacillus subtilis. PLoS Biol. 2004 Sep 21;2(10):E328. (PDF) Companion website.
Branda, S, Gonzalez-Pastor, J., Dervyn, E., Ehrlich, S., Losick, R., Kolter, R. Genes Involved in Formation of Structured Multicellular Communities by Bacillus subtilis. J. Bacteriol 186:3970-3979 (2004). (PDF)
van Ooij, C., Eichenberger, P., Losick, R. Dynamic Patterns of Subcellular Protein Localization during Spore Coat Morphogenesis in Bacillus subtilis. J. Bacteriol 186:4441-4448 (2004) (PDF)
Carniol, K., Kim T., Price, C. Losick, R. Insulation of the Sigma F Regulatory System in Bacillus subtilis J. Bacteriol 186:4390-4394 (2004). (PDF)
Gehring, A., Wang, S., Kearns, D., Storer, N., Losick R. Novel Genes That Influence Development in Streptomyces coelicolor. J. Bacteriol 186:3570-3577 (2004). (PDF)
Kearns, D., Chu , F., Rudner, R. and Losick, R. Genes governing swarming in Bacillus subtilis and evidence for a phase variation mechanism controlling surface motility. Molec. Microbiol 52:357-369 (2004). (PDF)
Carniol, K., Eichenberger, P., Losick, R. A Threshold Mechanism Governing Activation of the Developmental Regulatory Protein sf in Bacillus subtilis J. Biol. Chem. 279:14860-14870 (2004). (PDF)
Bentley, S.D., Brown, S., Murphy, L.D., Harris, D.E., Quail, M.A., Parkhill J., Barrell, B.G., McCormick, J.R., Santamaria, R.I., Losick, R., Yamasaki M., Kinashi, H., Chen, C.W., Chandra, G., Jakimowicz, D., Kieser, H. M., Kieser, T., and Chater, K.F. SCP1, a 356 023 bp linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolar A3(2) Molec. Microbiol. 51:1615-1628 (2004). (PDF)