Our Research

Overture

The goal of our laboratory is to build a multi-scale model that describes how a living brain interacts with its environment. To achieve this task, we study the brain of the larval zebrafish since it is the only genetically accessible vertebrate with a brain small enough to be observed in toto and at a cellular resolution while the animal is still alive. Our efforts focus on two primary approaches:

Act I:   Behavior

Visually Guided Behaviors

The OPTOMOTOR RESPONSE, is a robust reaction to the visual appearance of a moving world where the larvae attempts to follow the motion.

Somatosensory Behaviors

New Behavioral Recording Technology

In THE BEAST, high resolution videos of a larval zebrafish swimming in an extra-large tank are acquired by locking the camera's location to that of the fish

Act II:   Functional Imaging

Two Photon Point Scanning

Two photon point scanning, allows...

Volumetric Imaging

Using LIGHTSHEET MICROSCOPY, brain volumes are acquired at 1Hz

Act III:   Anatomical Reconstruction

Circuit Reconstruction

Using ELECTRON MICROSCOPY, individual neurons and circuits are being reconstructed across the brain

Coda:   Modeling