Motta SS, Cluzel P, Aldana M. Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps. PLoS ONE 10(3): e0118464. doi:10.1371/journal.pone.0118464 (2015)
Kevin B. Wood, Kris C. Wood, Satoshi Nishida, Philippe Cluzel. Uncovering scaling laws to infer multi-drug response of resistant microbes and cancer cells, Cell Reports. 6 (4): (2014)
Subramaniam A.R., Pan T., and Cluzel P. Environmental perturbations lift the degeneracy of the genetic code to regulate protein levels in bacteria, PNAS ; 110 (6): 2419-2424, (2013).
Wood K., Nishida S., Sontag E.D., and Cluzel P. Mechanism-independent method for predicting response to multidrug combinations in bacteria, PNAS ; 109 (30): 12254-9, (2012).
Wood K. and Cluzel P. Trade-offs between drug toxicity and benefit in the multi-antibiotic resistance system underlie optimal growth of E. coli, BMC Systems Biology ; 6(1): 48, (2012).
Moffitt J., Lee J.B., and Cluzel P. The single-cell chemostat: an agarose-based, microfluidic device for high-throughput, single-cell studies of bacteria and bacterial communities, Lab on a Chip ; 12(8): 1487-1494, (2012).
Park H., Oikonomou P., Guet C.C., and Cluzel P. Noise underlies switching behavior of the bacterial flagellum, Biophysical Journal ; 101(10): 2336-40. (2011).
Park H., Pontius W., Guet C.C., Marko J.F., Emonet T. and Cluzel P. Interdependence of behavioural variability and response to small stimuli in bacteria, Nature ; 468(7325): 819-23, (2010).
Park H., Guet C.C., Emonet T. and Cluzel P. Fine-tuning of chemotactic response in E. coli determined by high-throughput capillary assay, Current Microbiology ; 62(3): 764-9, (2011).
Guet C., Bruneaux L., Min T.L., Siegal-Gaskins D., Figueroa I., Emonet T. and Cluzel P. Minimally invasive determination of mRNA concentration in single living bacteria, Nucleic Acids Research ; 36(12):e73, (2008).
Pubmed | PDF | SI | Data
Emonet T. and Cluzel P. Relationship between cellular response and behavioral variability in bacterial chemotaxis, PNAS ; 105 (9), 3304-3309, (2008).
Oikonomou P. and Cluzel P. Effects of topology on network evolution, Nature Physics ; 2 (8), 532-536, (2006).
Le TT, Emonet T., Harlepp S., Guet CC, Cluzel P. Dynamical determinants of inducible gene expression in a single bacterium, Biophysical J. ; 90(9):3315-21, (2006).
Korobkova E., Emonet T., Park H, Cluzel P. Hidden stochastic nature of a single bacterial motor, Phys. Rev. Letters ; 96, 58105, (2006).
Le TT., Guet CC., Cluzel P. Protein expression enhancement in efflux-deleted mutant bacteria, Protein expression and purification ; 48(1):28-31, (2006).
Emonet T., Macal CM, North MJ, Wickersham CE, Cluzel P. AgentCell: a digital single-cell assay for bacterial chemotaxis, Bioinformatics ; 21(11):2714-21, (2005).
Le TT, Harlepp S., Guet CC, Dittmar K, Emonet T., Pan T., Cluzel P. Real-time RNA profiling within a single bacterium, PNAS ; 28; 102 (26):9160-4, (2005).
Korobkova E., Emonet T., Vilar J., Shimizu T. & Cluzel P. From molecular noise to behavioral variability in a single bacterium, Nature ; 428, 574-578, (2004).
Aldana M. and Cluzel P. A natural class of robust networks, PNAS ; 22;100(15):8710-4, (2003).
Bainer R, Park H. and Cluzel P. A high-throughput capillary assay for bacterial chemotaxis, J Microbiol Methods ; 55(1):315-9, (2003).
Cluzel P., Surette M, Leibler S. An ultrasensitive bacterial motor revealed by monitoring signaling proteins in single cells, Science ; 287: 1652-1655, (2000).
Manneville S., Cluzel P., Viovy J-L, Chatenay D, Caron F. Evidence for universal scaling behavior of a freely relaxing DNA molecule, Europhysics Letters ; 36: 413-418, (1996).
Cluzel P., Lebrun A., Heller C., Lavery R., Chatenay D., Caron F. DNA : An Extensible Molecule, Science ; 271: 792-794, (1996).
Viovy J-L, Heller C, Caron F, Cluzel P, Chatenay D. Ultrafast sequencing of DNA by mechanical opening of the double helix: a theoretical investigation, C.R. Acad. Sci. Paris ; 317: 795-800, (1994).